Sedating and non sedating antihistamines
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They accomplished this by blocking the histamine from connecting with its receptors in specific nerve, muscle and glandular types of cells.
This review summarizes the pharmacological properties of clinically useful non-sedating antihistamines from the perspective of histamine function in the CNS.
Non-sedating antihistamines are as effective as others but offer additional benefits.
The most significant advantage of non-sedating antihistamines is just what their mane implies: they do not have a sedative-like effect on the user.
Many sedating antihistamines do not require a doctor's prescription.
Sold over the counter (OTC), they are less expensive than prescription nonsedating antihistamines. Nonsedating antihistamines, also called new, or second-generation antihistamines, are just as effective against nasal allergy symptoms as older medications. They make you less sleepy and groggy, and are less likely to cause problems with increased eye pressure, which may worsen glaucoma symptoms.
Unlike regular antihistamines, non-sedating antihistamines do not activate the nerve cell receptors allowing them to generate the undesired response; they bind to them instead.